Having run all of the orientations at my store for the last year plus (my ETL just pops in to say hi and a few words) I would say that the best advice I can provide is as follows:
Have all new hire paperwork, new hire kits, name tags, and training schedules ready to go before the orientation starts. This will save you time from having to pause and do any of this while in progress. I gather all docs for I-9s and evaluate them before taking the class to the room. Later, you will have to do the I-9s and change them to hired in JAS to get their TM numbers, so I take the class with me to our room next door with a computer, where I have bottled water and a snack waiting to give them a break while i process their paperwork, then we're back on the orientation five minutes later, been having TM numbers generated very fast by operations lately. This makes it less awkward of leaving them in the room or having to get another TM to come by and facilitate while you are gone doing the paperwork. I do this between the videos and the handbook highlights. After the highlights, I have them do the rest of the paperwork and fill out their TM numbers on all of the docs before the guest activity and store tour.
Do you have a whiteboard in your orientation room? If so and it's not already there, write down the key points about attendance, eHR, lunch breaks, etc along with a who's who diagram of leadership and how LODs work. Define the terms STL, ETL, TL, and so on. This gives you a nice, organized list to go through.
ASANTS probably applies here as well, not sure if your store does any training during orientation, but mine does ladder safety and information security policy training at minimum so they're out of the way for day one. Sometimes we'll get the alcohol sales training done as well if there's time and the TMs are front end or sales floor.
Make sure they understand how bad a NCNS is in the first 90 days and best practice for day off requests.
Hope that helps you in some way!